BREAST CANCER CHEMOTHERAPY RESPONSE IN WAHIDIN SUDIROHUSODO HOSPITAL, MAKASSAR
Prihantono Prihantono, Haryasena Haryasena, Daniel Sampepajung
ABSTRACT Introduction: Treatments of breast cancer are multidisciplinary. Chemotherapy is one of the most important modalities and has become the standard of breast cancer treatment of in the adjuvant or neoadjuvant setting. Evaluation is needed in order to understand the effectivity of the chemotherapy regiment, to improve the service system and to share with other centers. Objectives: to understand the characteristics of chemotherapy patients, types of regimen, settings chemotherapy and neoadjuvant chemotherapy response of breast cancer. Methods: A retrospective study was done by reviewing the administrative data of cancer patients who were treated in the surgical oncology Wahidin Sudirohusodo Hospital, Makassar in 2014. Results: During 2014 has been carried out chemotherapy for 247 breast cancer patients, used as neoadjuvan setting 145 cases (59 %) and Adjuvan 102 cases (41%). The regimen used are CAF 155 cases ( 63%), TAC 55 cases ( 22 %), TA 20 cases (8%), GC 11 cases ( 5%), dan Vinoralbine 6 cases (2%). Cumulative Clinical Response are: complete response 3 cases (2%), partial response 112 cases (78%), stable disease 23 cases (15%), and progresive disease 9 (5%). Chemoterapy response by subtype: Luminal 67%, Her2 70%, Triple Negatif 88%. Conclusions: Breast cancer clinical response to various chemotherapy regimens are good, regimen and subtype affect the response to chemotherapy.
Keywords: breast cancer, chemotherapy, clinical response
DETECTION OF NONTUBERCULOUS MYCOBACTERIA (NTM) IN ISOLATES FROM SUSPECTED TUBERCULOSIS USING PCR IS6110 GENE
Andi Nur Asrinawaty, Muh Nasrum Massi, Rizalinda Sjahril
ABSTRACT Introduction: NTM is a group of mycobacterium other than M.tuberculosis complex and M.Leprae, which found in the environment and can be pathogenic. Objectives: This study aim was to detect NTM isolates using PCR on target genes IS 6110. Methods: This study was conducted in Laboratory of Microbiology, Faculty of Medicine, Hasanuddin University and Laboratorium microbiology in Hasanuddin University Hospital. 14 sample isolates of NTM from sputum of suspected tuberculosis patients. The method using PCR IS6110 gene. Results: The results showed that of 14 samples, 8 positive samples with M. tuberculosis and 6 samples negative. Conclusions: IS6110 PCR can be used to detect NTM isolates from sputum of suspected tuberculosis patients.
EFFECT OF BRAIN GYM ON COGNITIVE FUNCTION IN ELDERLY WITH POST ISCHEMIC STROKE
Jumraini Tammasse, Sri Wahyun
ABSTRACT Introduction: This study to determine brain gym practice effect on cognitive function of elderly post ischemic stroke. Methods: This study was an experimental test conducted at Makassar, South Sulawesi from June 23rd, 2014 to December 16th, 2014. Thirty two subjects were divided into experimental and control groups in the same number. The brain gym movements will be performed in the experimental group. Control group did not perform the brain gym movements. The experimental group exercised twice a week for twelve weeks. Pre-test and post-test using The Consortium to Establish Registry of Alzheimer Diseases – Neurophysiological Battery (CERAD- NB) was performed to all subjects before and after twelve weeks intervention. The difference of CERAD-NB score between pre-test and post-test was analyzed using Mann Whitney U and Wilcoxon Sink Rank Test. Results: The study showed there was a significant improvement on cognitive function in experimental group and a significant decline of cognitive function in the control group. There was also significant difference in CERAD-NB score with Mann Whitney test (p<0,05) between the experimental group and the control group. Brain gym gives a positive effect on cognitive function in the elderly with post ischemic stroke. Key words : Brain gym, cognitive function, elderly post ischemic strok
SPIRITUAL PSYCHOTHERAPY EFFECT TO INCREASE CD4+ COUNT IN HIV /AIDS PATIENTS
M Faisal Idrus, Jayalangkara Jayalangkara, Syamsu Syamsu, Ilham Ilham
ABSTRACT Introduction: HIV / AIDS is a viral infection that causes decrease of immunity system characterized by decrease CD4+ T lymphocyte counts. Low CD4 T-cell counts are considered due to destruction of lymphocytes T by human immunodeficiency virus. The spiritual psychotherapy is a form of psychiatric treatment that provides peace, and happiness of the soul. Peace of mind is expected to generate individual immune response. Objectives: Objective to determine the effect of spiritual psychotherapy to CD4 T-cell count. Methods: This is a quasi experimental study pretest-posttest control group design of 40 sample with HIV / AIDS who were selected by purposive sampling. This research was conducted in the HIV / AIDS Working Group and hospital inpatient BLU. Dr. Wahidin Sudirohusodo. Makassar. The samples were divided into two groups, the treatment group of 10 inpatient who received intensive spiritual psychotherapy, 10 sample from Lapas Bolangi and 20 control group who did not receive supportive psychotherapy. Statistical analysis using the Wilcoxon test. Results: The results of the analysis of CD4 + serum between the treatment and control groups was significantly different (p<0.05). After treatment, the CD4 T-cell count in the inpatient group increased serum from 15 to 160, but in the other groups (group bolangi from 446.50 to 365.50 and the control group from 424.5 to 201.0) was decreased, especially in the control group (Tables 2 and 3). Table 4 shows that of the 10 inpatient samples group, all had increased levels of CD4 + serum, whereas in the group Bolangi only 3 samples (30%) among the 10 sample of the control group , of 20 sample only 1 person (5%) had increase of CD4 + serum , and 19 sample (95%) had decrease. Keywords: Spiritual Psychotherapy – relaxation - CD4 count
THE ROLE OF HYPERLACTATEMIA STATUS AS A PROGNOSTIC PARAMETER IN CRITICALLY ILL NENONATES
A Dwi Bahagia, Ema Alasiry, Djauharia A.M, Hanna Kurniawati
ABSTRACT Introduction: Hypoxia and hypoperfussion is often found in neonates in an intensive care unit, however the clinical manifestations can only be found after cellular hypoxia and tissue perfussion disorder occur. Objective: The study aims to find the ability of hyperlactatemia status as a prognostic parameter for infants in Neonatal Intensive Care Unit Level IIIA. Methods : The research was a cohort prospective study using bivariat and multivariat analysis in NICU of Dr. Wahidin Sudirohusodo Hospital from June 2012 to April 2013. The analysis of the lactate level on samples that met the inclusion and exclusion criterias was done immediately after the neonates get into the NICU level IIIA. The capliary lactate level was measured using hand held analyser. The samples were distributed into groups of hyperlactatemia and without hyperlactatemia followed by outcome observation (death or good recovery). The number of subjects were 102 patients consisted of 69 males and 33 females. Results : The study showed the incidence of hyperlactatemia at NICU leve IIIA was 53,9%. Hyperlactatemia ((p=0.000; IK95% 4.11-56.75.00; AOR 15.28) and chronological age <24 hours (p=0.014; IK95% 1.5037.04; AOR 7.47) was significant in determining the patient’s outcome. Conclusions: The study found that hyperlactatemia status and cronological age less than 24 hours were prognostic factors for patient’s outcome related to elevated mortality risk. Keywords: Hyperlactatemia, NICU, Critically ill infants
ABSTRACT Introduction: It has been reported that obese children have a higher incidence of high ferritin and transferrin saturation than non obese children. The excessive iron stores can cause type 2 diabetes among patients with hemochromatosis, and this event could also occurred in obesity. Objectives: This study sought to know the level of serum ferritin and iron (ferrum) in adolescent obesity which could lead to initiate insulin resistance. Methods: Fifty five adolescence women (3 obese, 22 overweight, and 30 normal weight) involved in this study. The obesity was determined by body mass index (BMI), which are obese if BMI > 30 kg/m2; overweight if BMI 25-30 kg/m2; and normal weight if BMI < 25 kg/m2. The serum level of iron and ferritin assessed by kit analyzer with immunochemiluminescent methods, after drawing 2 ml blood from cubital vein. Conclusions: We concluded that serum ferritin and iron (ferrum) higher in obese group than overweight and normal weight group, although it was not statistically significance (Kruskall Wallis test p > 0.05). It was appeared that serum ferritin and iron tended to elevated following the raising of body mass index (BMI).
Keywords : obesity, serum ferritin, serum iron (ferrum)
