BREAST CANCER CHEMOTHERAPY RESPONSE IN WAHIDIN SUDIROHUSODO HOSPITAL, MAKASSAR

Article History

Submited : August 3, 2017
Published : March 17, 2016

ABSTRACTIntroduction: Treatments of breast cancer are multidisciplinary. Chemotherapy isone of the most important modalities and has become the standard of breast cancertreatment of in the adjuvant or neoadjuvant setting. Evaluation is needed in order tounderstand the effectivity of the chemotherapy regiment, to improve the servicesystem and to share with other centers. Objectives: to understand thecharacteristics of chemotherapy patients, types of regimen, settings chemotherapyand neoadjuvant chemotherapy response of breast cancer. Methods: Aretrospective study was done by reviewing the administrative data of cancer patientswho were treated in the surgical oncology Wahidin Sudirohusodo Hospital, Makassarin 2014. Results: During 2014 has been carried out chemotherapy for 247 breastcancer patients, used as neoadjuvan setting 145 cases (59 %) and Adjuvan 102cases (41%). The regimen used are CAF 155 cases ( 63%), TAC 55 cases ( 22%), TA 20 cases (8%), GC 11 cases ( 5%), dan Vinoralbine 6 cases (2%).Cumulative Clinical Response are: complete response 3 cases (2%), partialresponse 112 cases (78%), stable disease 23 cases (15%), and progresive disease9 (5%). Chemoterapy response by subtype: Luminal 67%, Her2 70%, Triple Negatif88%. Conclusions: Breast cancer clinical response to various chemotherapyregimens are good, regimen and subtype affect the response to chemotherapy.Keywords: breast cancer, chemotherapy, clinical response

References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer
  2. statistics. CA: a cancer journal for clinicians. 2011;61(2):69-90.
  3. Wahidin M, Noviani R, Hermawan S, Andriani V, Ardian A, Djarir H. Population-based cancer registration in Indonesia. Asian Pac J Cancer Prev. 2012;13(4):1709-1710.
  4. Rhodes A, Yip C. Comparison of breast cancer in Indonesia and
  5. Malaysia–a clinico-pathological study between Dharmais Cancer Centre
  6. Jakarta and University Malaya Medical Centre, Kuala Lumpur. Asian Pacific Journal of Cancer Prevention. 2011;12:2943-2946.
  7. Cardoso F, Bedard PL, Winer EP, Pagani O, Senkus-Konefka E, Fallowfield LJ, et al. International guidelines for management of metastatic breast cancer: combination vs sequential single-agent chemotherapy. Journal of the National Cancer Institute. 2009;101(17):1174-1181.
  8. Gong C, Yao H, Liu Q, Chen J, Shi J, Su F, et al. Markers of tumor-initiating
  9. cells predict chemoresistance in breast cancer. PloS one. 2010; 5(12):e15630.
  10. Kaufmann M, Hortobagyi GN, Goldhirsch A, Scholl S, Makris A, Valagussa P, et al. Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer:
  11. an update. Journal of Clinical Oncology. 2006;24(12):1940-1949.
  12. Connolly RM, Stearns V. Current approaches for neoadjuvant chemotherapy in breast cancer. European journal of pharmacology. 2013;717(1):58-66.
  13. Eisenhauer E, Therasse P, Bogaerts J, Schwartz L, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). European journal of cancer. 2009;45(2):228-247.
  14. Denkert C, Sinn BV, Issa Y, Müller BM, Maisch A, Untch M, et al. Prediction of response to neoadjuvant chemotherapy: new biomarker approaches and concepts. Breast Care. 2011;6(4):265-272.
  15. Knoop AS, Knudsen H, Balslev E, Rasmussen BB, Overgaard J, Nielsen KV, et al. Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients
  16. randomly assigned to cyclophosphamide, methotrexate, and
  17. fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish
  18. Breast Cancer Cooperative Group. Journal of Clinical Oncology. 2005;23(30):7483-7490.
  19. Rastogi P, Anderson SJ, Bear HD, Geyer CE, Kahlenberg MS, Robidoux A, et al. reoperative chemotherapy: updates of national surgical adjuvant
  20. breast and bowel project protocols B- 18 and B-27. Journal of Clinical Oncology. 008;26(5):778-785.
  21. Kong X, Moran MS, Zhang N, Haffty B, Yang Q. Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable
  22. prognosis for breast cancer patients. European Journal of Cancer. 2011;47(14):2084-2090.
  23. Kuerer HM, Newman LA, Smith TL, Ames FC, Hunt KK, Dhingra K, et al. Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy. Journal
  24. of Clinical Oncology. 1999;17(2):460-.
  25. Luangdilok S, Samarnthai N, Korphaisarn K. Association between Pathological Complete Response and Outcome Following Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients. Journal of breast cancer. 2014;17(4):376-385.
  26. Youlden DR, Cramb SM, Yip CH, Baade PD. Incidence and mortality of female breast cancer in the Asia-Pacific region. Cancer biology & medicine. 2014;11(2):101.
  27. Howlader N, Noone A, Krapcho M, Garshell J, Neyman N, Altekruse S, et al. SEER Cancer Statistics Review, 1975-2010.[Based on the November 2012 SEER data submission, posted
  28. to the SEER web site, April 2013.]. Bethesda, MD: National Cancer Institute. 2013.
  29. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer. 2010;127(12):2893-2917.
  30. DeSantis C, Siegel R, Bandi P, Jemal A. Breast cancer statistics, 2011. CA: a cancer journal for clinicians. 2011;61(6):408-418.
  31. Kouame JND, Troh E, Kouakou EK, Doukouré B, Kouame AD, Abouna AD, et al. Epidemiology and Histology Aspects of Breast Cancers of Women in Ivory Coast. Journal of Cancer Therapy. 2012;3(05):782.
  32. Engstrom M, Opdahl S, Hagen A, Romundstad P, Akslen L, Haugen O, et al. Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients. Breast cancer research and treatment. 2013;140(3):463-473.
  33. Lv M, Li B, Li Y, Mao X, Yao F, Jin F. Predictive role of molecular subtypes in response to neoadjuvant chemotherapy in breast cancer patients in Northeast China. Asian Pacific journal of cancer prevention: APJCP. 2010;12(9):2411-2417.
  34. Parise CA, Caggiano V. Breast cancer survival defined by the ER/PR/HER2 subtypes and a surrogate classification according to tumor grade and immunohistochemical biomarkers.
  35. Journal of cancer epidemiology. 2014;2014.
  36. Haque R, Ahmed SA, Inzhakova G, Shi J, Avila C, Polikoff J, et al. Impact of breast cancer subtypes and treatment on survival: an analysis spanning two decades. Cancer Epidemiology Biomarkers & Prevention. 2012;21(10):1848-1855.
  37. Kuo W-H, Yen AM-F, Lee P-H, Hou M-F, Chen S-C, Chen K-M, et al. Incidence and risk actors associated with bilateral breast cancer in area with early age diagnosis but low
  38. incidence of primary breast cancer: analysis of 10-year longitudinal cohort in Taiwan. Breast cancer research and treatment. 2006;99(2):221-228.
  39. Kaufmann M, von Minckwitz G, Mamounas EP, Cameron D, Carey LA, Cristofanilli M, et al. Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer. Annals of surgical oncology. 2012;19(5):1508-1516.
  40. Cortazar P, Zhang L, Untch M, Mehta K, Costantino J, Wolmark N, et al. Meta-analysis esults from the collaborative trials in neoadjuvant breast cancer (CTNeoBC). Cancer Research. 2012;72(24 Supplement):S1-11.
  41. Rouzier R, Perou CM, Symmans WF, Ibrahim N, Cristofanilli M, Anderson K, et al. Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clinical Cancer Research. 2005;11(16):5678-5685.
Prihantono, P., Haryasena, H., & Sampepajung, D. (2016). BREAST CANCER CHEMOTHERAPY RESPONSE IN WAHIDIN SUDIROHUSODO HOSPITAL, MAKASSAR. Nusantara Medical Science Journal, (1), 1-9. https://doi.org/10.20956/nmsj.v0i1.2202

Downloads

Download data is not yet available.
Fulltext