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The Relationship Between Histopathological Grading and Metastasis in Colorectal Carcinoma Patients

DOI: https://doi.org/10.20956/nmsj.v5i2.8786
Article History

Submited : December 21, 2019
Published : April 5, 2021

Keywords:
Introduction: To Colorectal cancer (CRC) is a malignancy in the large intestine caused by uncontrolled cell growth. The cause of death due to metastasis and the prognosis is determined by the stage that can be assessed using Dukes classification or TNM (Tumor Nodes Metastasis) staging system. Determination of histopathological grading is important because of the differences in radiosensitivity, local behaviour and the metastasis tendency. The aim of this study is to determine the relationship between histopathological grading and metastasis in colorectal cancer patients. Methods:  This study is a cross-sectional study using secondary data from the medical records of CRC patients at the RS. Dr. Wahidin Sudirohusodo and its networking hospital, that were obtained by consecutive sampling. Inclusion criteria are all patients who had surgery and have the results of histopathology, radiology and other datas that may be used as a reference for determining the staging based on the Dukes classification and TNM staging system Results: The number of CRC patients during January 2008 to April 2012 was 268 patients, 55,6% of them were males and mostly their age were around 51-60 years old (25,4%). Most of the CRC location was in the rectum (61,2%) and the highest number of metastasis location was in lymph nodes (40,4%).  Out of 179 patients who had result of histopathological examination, adenocarcinoma type (100%) and moderately differentiated adenocarcinoma (45,3%) were the most frequently histopathological grading found. Most of the CRC stage based on the TNM staging system was stage IV (27,4%) and based on the Dukes classification was stage D (26,8%).   There is a significant relationship (p<0,001) between histopathological grading and metastasis, and it showed that poorly differentiated adenocarcinoma was more frequent in advanced stage, based on both the Dukes classification and TNM staging system. Conclusions: There is a significant relationship between histophological grading and metastasis. Poorly differentiated adenocarcinoma is more likely to be found in advanced stage of CRC.

References

  1. Singapore Ministry of Health. Colorectal cancer. Health promotion board. 2009. Available at: http://www.hpb.gov.sg. Accessed September 27, 2011.
  2. World Health Organization. Cancer. 2011. Available at: http://www.who.int/ cancer/en/. Accessed September 27, 2011.
  3. Kelompok kerja Karsinoma kolorektal. Pengelolaan karsinoma kolorektal. Panduan klinis nasional. Revisi 2006.pp5-56
  4. Lavery IC, Kostner FL, Pelley RJ, et al. Treatment of colon and rectal cancer. Surg Clin North Am. 2000;80(2):535-69.
  5. Pezzoli A, Matarese V, Rubini M, et al. Colorectal cancer screening: results of a 5-year program in asymptomatic subjects at increased risk. Dig Liver Dis.2007;39(1):33-9.
  6. Marzouk O, Schofield J. Review of histopathological and molecular prognostic features in colorectal cancer. Cancers. 2011; 3: 2767-810.
  7. Mendenhall WM, Bland KI, Copeland EM, et al. Does preoperative radiation therapy enhance the probability of local control and survival in high-risk distal rectal cancer. Ann Surg. 1992;215(6):696-705.
  8. Rosai J. Gastrointestinal track In: Ackerman's Surgical Pathology. 9th ed. St. Louis: Mosby, 2004; pp 750-858.
  9. National Cancer Institute. Colon and rectal cancer. Cancer topics. 2011. Available at: http://www.cancer.gov/ cancertopics/pdq. Accessed September 27th, 2011.
  10. McQuaid KR. Alimentary tract cancer. In Tierney JR, et al (eds). Current Medical Diagnosis and Treatment 2008. Stamford, CT: Appleton and Lange. 2008; pp1411-16.
  11. Nabi U, Nagi AH, Riaz S. Morphological evaluation of colorectal carcinoma with grading staging and histological types. J Pak Med Assoc. 2010 Dec;60(12):998-1001.
  12. Chung CK, Zaino RJ, St ryker JA. Colorectal carcinoma: evaluation of histologic grade and factors influencing prognosis. J Surg Oncol. 1982; 21:143-8.
  13. Cancer Research UK. Bowel (colorectal) cancer - UK incidence statistics. http://info. cancerresearchuk.org/cancerstats/types/bowel/incidence/uk-bowel-cancer-incidence-statistics. Accessed 20th May, 2012.
  14. Dayal Y, DeLellis R. The gastrointestinal tract. In: Cotran RS, Kumar V, Robbins SL (eds). Robbins Pathologic Basis of Disease. 4th ed. Philadelphia: Saunders. 1989:897-8.
  15. Nautiyal J, Du J, Yu Y, et al. EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine. Am J Physiol Gastrointest Liverl. 2012;302(7):G655-63.
Minhajat, R., Benyamin, A. F. ., & Miskad, U. A. . (2021). The Relationship Between Histopathological Grading and Metastasis in Colorectal Carcinoma Patients. Nusantara Medical Science Journal, 5(2), 51-60. https://doi.org/10.20956/nmsj.v5i2.8786

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