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THE DIFFERENCE HUMAN LEUKOCYTE ANTIGEN-E (HLA-E) EXPRESSION AND NATURAL KILLER CELLS (NK CELLS) IN TROPHOBLAST BETWEEN INTRAUTERINE GROWTH RESTRICTION (IUGR) AND NORMAL PREGNANCY

DOI: https://doi.org/10.20956/nmsj.v3i1.5781
Article History

Submited : December 26, 2018
Published : June 1, 2018

Keywords:
Background: Intrauterine growth restriction (IUGR) is still a major cause of perinatal morbidity and mortality. IUGR incidence ranged from 4.4 to 6.44% of pregnant women. Human Leukocyte Antigen - E and NK cells are thought to play an important role towards the process of IUGR.Objective: To determine aetiopathogenesis HLA-E expression and NK Cell in IUGR.Methods: An analytical observational study conducted through a cross-sectional approach. The research was conducted on March-October 2015 at the Obstetrics and Gynecology Department, Dr. Moewardi Hospital Surakarta and at of Laboratory of Pathology, Faculty of Medicine, Universitas Sebelas Maret Surakarta. Subjects who meet the inclusion and exclusion criteria consisted of 20 patients with IUGR and 20 normal pregnant patient. The researcher examined HLA-E Expression and NK cells in trophoblast using immunohistochemical method and statistical analysis using t test.Results: The average HLA-E expression in the trophoblast in IUGR group 17.80 ± 5.55, compared with normal pregnancy 66.23 ± 19.83, p value = 0.0001 (p <0.05). The average expression of NK cells in trophoblast in IUGR group 137.71 ± 28.09 compared with normal pregnancy 31.75 ± 14.77, p value = 0.0001 (p <0.05).Conclusion: HLA-E expression in normal pregnancy trophoblast is higher than pregnancies with IUGR. Expression of NK cells in pregnancy with IUGR is higher compared with normal pregnancy.

References

  1. Figueras, F., Gardosi, J., 2011. Intrauterine Growth Restriction: New Concepts in Antenatal Surveillance, Diagnosis, and Management. American Journal of Obstetric and Gynecology, Vol. 4. Hlm. 288-300
  2. Himpunan Kedokteran Fetomaternal Indonesia, 2012. Panduan Penatalaksanaan Kasus Obstetri, Himpunan Kedokteran Fetomaternal Perkumpulan Obstetri dan Ginekologi Indonesia. Editor: Karkata M.K., Kristanto H. 5: 79-105
  3. Sumawan, H., Purwara, B.P., Krisnadi, S.R., 2013. Low Maternal Leptin Levels in Preeclamptic Women with Fetal Growth Restriction. Open Journal of Obstetrics and Gynecology. Vol.3, hlm. 536-540
  4. Eastabrook, G., Hu, Y., Dadelszen, P.V., 2008. The Role of Decidual Natural Killer Cells in Normal Placentation and in the Pathogenesis of Preeclampsia. JOGC, Juni. Hlm. 467-476.
  5. Tripathi, P., Naik, S., Agrawal, S., 2007. Role of HLA-G, HLA-E and KIR2DL4 in Pregnancy. International Journal of Human Genetic. Vol. 7, no. 3, hlm. 219-233.
  6. Nieuwenhoven, A.L.V., Heineman, M.J., Faas, M.M., 2003. The Immunology of Successful Pregnancy. Human Reproduction Update, Vol.9, no.4. hlm. 347-357.
  7. Raghupathy, R., Al-Azemi, M., Azizieh, F.. 2012. Intrauterine Growth Restriction: Cytokine Profiles of Trophoblast Antigen-Stimulated Maternal Lymphocytes. Clinical and Developmental Immunology, Vol. 2012. Hlm 1-11.
  8. Murti, B., 2010. Desain dan Ukuran Sampel untuk Penelitian Kuantitatif dan Kualitatif di Bidang Kesehatan. Gadjah Mada University Press, Yogyakarta.
  9. Barut, F., Barut, A., Gun, B.D., Kandemir, N.O., Harma, M.I., Harma, M., Aktunc, E., Ozdamar, S.O., 2010. Intrauterine Growth Restriction and Placental Angiogenesis. Diagnostic Pathology, Vol.5, no. 24. Hlm. 1-7.
  10. Moffett, A., Colucci, F., 2014. Uterine NK Cells: Active Regulators at the Maternal-Fetal Interface. Journal of Clinical Investigation. Vol.124, No.5, hal 1872-1879.
  11. Vesce, F., Cagnazzo, E., Giugliano, E., Mossuto, R., Marci, R. 2014. The Behaviour of the Peripheral Natural Killer Cells in the Foetal Growth Restriction. European Review for Medical and Pharmacological Sciences. Vol. 18, hlm. 2248-2252.
  12. Kieckbusch, J., Gaynor, L.M., Moffett, A., Colucci, F., 2014., MHC-dependent Inhibition of Uterine NK Cells Impedes Fetal Growth and Decidual Vascular Remodelling. Nature Communications. Vol. 5, No. 3359, hlm. 1-12
  13. Bhalla, A., Stone, P.R., Liddell, H.S., Zanderigo, A., Chamley, L.W., 2006. Comparison of The Expression of Human Leukocyte Antigen (HLA)-G and HLA-E in Women with Normal Pregnancy and Those with Recurrent Miscarriage. Reproduction, Vol. 131, hlm. 583-589.
  14. Mallia, J.V., Das, D.K., Maitra, A., 2012. Role of HLA in Human Pregnancy. International Journal of Human Genetic, Vol.12, no.1. hlm. 33-36.
soetrisno, soetrisno, Sulistyowati, S., Respati, S. H., & Cahyadi, B. T. (2018). THE DIFFERENCE HUMAN LEUKOCYTE ANTIGEN-E (HLA-E) EXPRESSION AND NATURAL KILLER CELLS (NK CELLS) IN TROPHOBLAST BETWEEN INTRAUTERINE GROWTH RESTRICTION (IUGR) AND NORMAL PREGNANCY. Nusantara Medical Science Journal, 3(1), 15-19. https://doi.org/10.20956/nmsj.v3i1.5781

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