PHYTOCEMICAL ANALYSIS AND ANTI OKSIDANT ACTIVITY OF THE WOOD ETHANOLIC EXTRACTS OF SIRIH HUTAN (Pipe aduncum)

Erwin Erwin

doi:10.20956/ica.v8i2.2468

Submitted

Sep 15, 2017

Accepted

Sep 15, 2017

Published

Dec 1, 2015

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Abstract

Sirih hutan (Piper aduncum) grew evenly in the tropical rain forests of East Kalimantan; it was used as a drug itching by local people. The present study is aimed to determine the chemical content and evaluate the free radical scavenging potential antioxidant activity of the extract of Sirih hutan wood. Based on the results of the GC-MS of the wood extract of Sirih hutan consists of 11 compounds. The inhibition of DPPH scavenging free radicalst of extract in ethanol preparations is IC50 259.74 ppm.

Keywords

Sirih hutan antioxidant activity GC-MS

How to Cite

Erwin, E. (2015). PHYTOCEMICAL ANALYSIS AND ANTI OKSIDANT ACTIVITY OF THE WOOD ETHANOLIC EXTRACTS OF SIRIH HUTAN (Pipe aduncum). Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta), 8(2), 11-16. https://doi.org/10.20956/ica.v8i2.2468

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References

Adelakun, O, E., Kudanga, T, Green, I.R., Hill, M.l.R., and, Burton, S, G. Enzymatic modification of 2,6- dimethoxyphenol for the synthesis of dimers with high antioxidant capacity, Research and Postgraduate Studies, University of Pretoria, Pretoria 0002, SouthAfrica, http://repository.up.ac.za/bitstream/handle/2263/21113/Adelakun Enzymatic%282012%29.pdf?sequence=1, 27 July 2015
Brazao, M. A.B., Brazao, F.V., Maia, J.G.S., and Monteiro, M.C., 2014, Antibacterial activity of the Piper aduncum oil and dillapiole, its main constituent, against multidrug-resistant strains, Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas,13 (6): 517 – 526
Seo Young Choi, S.Y., Chung, J.H., Kim, D.H., Chung, S.W., Kim, J.W., Yu, B.P., Chung, H.Y., 2007, Peroxisome proliferator-activated receptor gamma agonist action of 3- methyl-1,2-cyclopentanedione, Vol.1770 (12), 1612–1619
Danelutte A, Lago J, Young M, Kato M 2003. Antifungal flavanones and prenylated hydroquinones from Piper crassinervium Kunth. Phytochemistry, 64: 555-559
Dyer, L.A. and Aparna Palmer, D. N. 2004, Piper : A Model Genus for Studies of Phytochemistry, Ecology, and Evolution, Kluwer Academic/Plenum Publishers, New York Boston, Dordrecht, London, Moscow.
Jun, M.H.Y., Yu., J., Fong, X., Wan, C.S,Yang, C.T. and Ho. 2003. Comparisonof antioxidant activities of isoflavones from kudzu root (Pueraria labata Ohwl). J. Food Sci. Institute of Technologist. 68: 2117–2122.
López A, Sheng D, Towers N. 2002. Antifungal activity of benzoic acid derivatives from Piper lanceaefolium. J Nat Prod, 65: 62-64.
Munawaroh, E. I.P. Astuti dan Sumanto, 2009, Potential Exploration of Piper SPP from Suaka Alam Maninjau Utara-Selatan and Batang Pangean II As Ornamental and Medicinal plants, Proceeding Seminar nasional : Peran Biosistimatika, Purwekorto, 35-38
Marques, A.M. and Kaplan, M.A.C., 2015, Active metabolites of the genus Piper against Aedes aegypti: natural alternative sources for dengue vector control, Univ. Sci., Vol. 20 (1): 61-82.
Martínez, R.R., Arrieta , J., Antonio, L.C., Baez , D.A., Méndez, A.M.V., and Mendoza, M.S.E., 2013, Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats, Molecules, 2013, 11327-11337
Orjala, J. Wright, A.D., Folkers, G, and Sticher, O. 1994, Cytotoxic and antibacterial dihidrochalcones from Piper aduncum, Journal of Natural Product, Vol. 57 (1), 18-26
Padmanaba, M., and Sheil, D. 2014, Spread of the invasive alien species Piper aduncum via logging roads in Borneo, Tropical Conservation Science, Vol.7 (1):35-4 , 2014
Ramirez, J., Cartuche, L., Morocho, V., Aguilar, S., and Malagon, O. 2013, Antifungal activity of raw extract and flavanons isolated from Piper ecuadorense from Ecuador, Revista Brasileira de Farmacognosia Brazilian Journal of Pharmacognosy, 23 (2):
-373.
Sudrajat, Dwi Susanto, A. Rahman, 2010, The toxicity of bark extract of Sirih hutan (Piper aduncum. LINN), Bioprospek, 7 (1), 90-94
Sumathykutty, M.A., Rao, J.M., Padmakumari, K.P., & Narayanan, C.S., 1999. Essential oil constituents of some Piper species. Flavour Fragrance. J., 14, 279 - 282.
Wan, Y.Y, Du, Y.M., and Miyakoshi, T, 2008, Enzymatic catalysis of 2,6- dimethoxyphenol by lactases and products characterization in organic solutions, Science in Chine Series: Chemistry, 51(7), pp 669-676

References

Adelakun, O, E., Kudanga, T, Green, I.R., Hill, M.l.R., and, Burton, S, G. Enzymatic modification of 2,6- dimethoxyphenol for the synthesis of dimers with high antioxidant capacity, Research and Postgraduate Studies, University of Pretoria, Pretoria 0002, SouthAfrica, http://repository.up.ac.za/bitstream/handle/2263/21113/Adelakun Enzymatic%282012%29.pdf?sequence=1, 27 July 2015

Brazao, M. A.B., Brazao, F.V., Maia, J.G.S., and Monteiro, M.C., 2014, Antibacterial activity of the Piper aduncum oil and dillapiole, its main constituent, against multidrug-resistant strains, Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas,13 (6): 517 – 526

Seo Young Choi, S.Y., Chung, J.H., Kim, D.H., Chung, S.W., Kim, J.W., Yu, B.P., Chung, H.Y., 2007, Peroxisome proliferator-activated receptor gamma agonist action of 3- methyl-1,2-cyclopentanedione, Vol.1770 (12), 1612–1619

Danelutte A, Lago J, Young M, Kato M 2003. Antifungal flavanones and prenylated hydroquinones from Piper crassinervium Kunth. Phytochemistry, 64: 555-559

Dyer, L.A. and Aparna Palmer, D. N. 2004, Piper : A Model Genus for Studies of Phytochemistry, Ecology, and Evolution, Kluwer Academic/Plenum Publishers, New York Boston, Dordrecht, London, Moscow.

Jun, M.H.Y., Yu., J., Fong, X., Wan, C.S,Yang, C.T. and Ho. 2003. Comparisonof antioxidant activities of isoflavones from kudzu root (Pueraria labata Ohwl). J. Food Sci. Institute of Technologist. 68: 2117–2122.

López A, Sheng D, Towers N. 2002. Antifungal activity of benzoic acid derivatives from Piper lanceaefolium. J Nat Prod, 65: 62-64.

Munawaroh, E. I.P. Astuti dan Sumanto, 2009, Potential Exploration of Piper SPP from Suaka Alam Maninjau Utara-Selatan and Batang Pangean II As Ornamental and Medicinal plants, Proceeding Seminar nasional : Peran Biosistimatika, Purwekorto, 35-38

Marques, A.M. and Kaplan, M.A.C., 2015, Active metabolites of the genus Piper against Aedes aegypti: natural alternative sources for dengue vector control, Univ. Sci., Vol. 20 (1): 61-82.

Martínez, R.R., Arrieta , J., Antonio, L.C., Baez , D.A., Méndez, A.M.V., and Mendoza, M.S.E., 2013, Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats, Molecules, 2013, 11327-11337

Orjala, J. Wright, A.D., Folkers, G, and Sticher, O. 1994, Cytotoxic and antibacterial dihidrochalcones from Piper aduncum, Journal of Natural Product, Vol. 57 (1), 18-26

Padmanaba, M., and Sheil, D. 2014, Spread of the invasive alien species Piper aduncum via logging roads in Borneo, Tropical Conservation Science, Vol.7 (1):35-4 , 2014

Ramirez, J., Cartuche, L., Morocho, V., Aguilar, S., and Malagon, O. 2013, Antifungal activity of raw extract and flavanons isolated from Piper ecuadorense from Ecuador, Revista Brasileira de Farmacognosia Brazilian Journal of Pharmacognosy, 23 (2):

-373.

Sudrajat, Dwi Susanto, A. Rahman, 2010, The toxicity of bark extract of Sirih hutan (Piper aduncum. LINN), Bioprospek, 7 (1), 90-94

Sumathykutty, M.A., Rao, J.M., Padmakumari, K.P., & Narayanan, C.S., 1999. Essential oil constituents of some Piper species. Flavour Fragrance. J., 14, 279 - 282.

Wan, Y.Y, Du, Y.M., and Miyakoshi, T, 2008, Enzymatic catalysis of 2,6- dimethoxyphenol by lactases and products characterization in organic solutions, Science in Chine Series: Chemistry, 51(7), pp 669-676

PHYTOCEMICAL ANALYSIS AND ANTI OKSIDANT ACTIVITY OF THE WOOD ETHANOLIC EXTRACTS OF SIRIH HUTAN (Pipe aduncum)

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