KOMORBIDITAS DIABETES MELLITUS TERHADAP MANIFESTASI KLINIK DAN KUALITAS HIDUP PADA PENDERITA TUBERKULOSIS PARU
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Abstract
Komorbiditas diabetes mellitus dapat menjadi beban ganda (double burden) dalam penyelesaian penyakit menular dan kronik, hal ini terjadi karena TB dan DM berinteraksi satu sama lain yang dapat menyebabkan pelaksanaan pengobatan klinis menjadi lebih sulit dibandingkan dengan pengobatan pada penyakit tunggal TB atau DM. Penelitian ini bertujuan menganalisis besar risiko diabetes mellitus terhadap manifestasi klinikdan kualitas hidup pada penderita TB-DM dan TB tanpa DM. Jenis penelitian yang digunakan adalah observasional analitik dengan rancangan prospectif cohort study. Total sampel sebanyak 60 orang terdiri dari, 30 orang TB-DM dan 30 orang TB tanpa DM. Penarikan sampel dilakukan dengan purposive sampling. Data dianalisis menggunakan uji RR. Hasil penelitian menunjukkan bahwa DM meningkatkan risiko terhadap keparahan penyakit (RR=1,89;95%CI=1,01-3,55), gejala TB paru (RR=1,43;95%CI=0,90–2,26), dan kualitas hidup (RR=1,82;95%CI=1,07–3,10). Namun, adanya DM merupakan faktor protektif terjadinya status gizi tidak normal pada penderita TB paru (RR=0,80;95%CI=0,74–2,64). Setelah dilakukan analisis secara simultan menunjukkan bahwa DM berpengaruh terhadap manifestasi klinik dan kualitas hidup pada penderita TB paru.
References
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10. Magee, M. J. et al. Diabetes Mellitus and Risk of All-Cause Mortality among Patients with Tuberculosis in the State of Georgia, 2009–2012. Annals of epidemiology. 2014;(24):369-75.
11. Dooley, K. E. et al. Impact of Diabetes Mellitus on Treatment Outcomes of Patients with Active Tuberculosis. The American journal of tropical medicine and hygiene. 2009;(80):634-39.
12. Peleg, A. Y. et al. Common Infections in Diabetes: Pathogenesis, Management and Relationship to Glycaemic Control. Diabetes/metabolism research and reviews. 2007;(23):3-13.
13. Gearhart, M. M. & Parbhoo, S. K. Hyperglycemia in the Critically Ill Patient. AACN Advanced Critical Care.2006;(17):50-55.
14. Kapur, A. & Harries, A. D. The Double Burden of Diabetes and Tuberculosis–Public Health Implications. Diabetes Research and Clinical Practice. 2013;(101):10-19.
15. Khariroh & Syamilatul. Faktor Resiko Gagal Konversi BTA Sputum Penderita TB Paru Setelah Program Pengobatan DOTS Fase Intensif di RSU Dr. Soetomo dan PB4 Karang Tembok Surabaya [Tesis]. Surabaya: Universitas Airlangga; 2006.
2. Alisjahbana, B. et al. The Effect of Type 2 Diabetes Mellitus on the Presentation and Treatment Response of Pulmonary Tuberculosis. Clinical Infectious Diseases. 2007;(45):428-35.
3. Viswanathan, V. et al. Prevalence of Diabetes and Pre-Diabetes and Associated Risk Factors among Tuberculosis Patients in India. PLoS One. 2012: 7.
4. Wang, Q. et al. Rationale and Design of a Randomized Controlled Trial of the Effect of Retinol and Vitamin D Supplementation on Treatment in Active Pulmonary Tuberculosis Patients with Diabetes. BMC infectious diseases. 2013;(13):104.
5. Faurholt-Jepsen, D. et al. Diabetes is a Strong Predictor of Mortality During Tuberculosis Treatment: a Prospective Cohort Study among Tuberculosis Patients from Mwanza, Tanzania. Tropical Medicine & International Health.2013;(18):822-29.
6. Paton, N. I. et al. Randomized Controlled Trial of Nutritional Supplementation in Patients with Newly Diagnosed Tuberculosis and Wasting. The American journal of clinical nutrition. 2004;(80):460-65.
7. Balakrishnan, S., Prema J, Sunil Kumar M, Nair S & Pk, D. Diabetes Mellitus Increases Risk of Failing Treatment in Drug Susceptible TB patients. International Journal of Tuberculosis and Lung Disease; 2011.
8. Brostrom, R. J. Summary of the Impact of Diabetes on Tuberculosis Control and Submission of Draft Standards for Diabetes and Tuberculosis in the US-affiliated Pacific Islands; 2010.
9. Duangrithi, D. et al. Impact of Diabetes Mellitus on Clinical Parameters and Treatment Outcomes of Newly Diagnosed Pulmonary Tuberculosis Patients in Thailand. International journal of clinical practice. 2013;(67):1199-209.
10. Magee, M. J. et al. Diabetes Mellitus and Risk of All-Cause Mortality among Patients with Tuberculosis in the State of Georgia, 2009–2012. Annals of epidemiology. 2014;(24):369-75.
11. Dooley, K. E. et al. Impact of Diabetes Mellitus on Treatment Outcomes of Patients with Active Tuberculosis. The American journal of tropical medicine and hygiene. 2009;(80):634-39.
12. Peleg, A. Y. et al. Common Infections in Diabetes: Pathogenesis, Management and Relationship to Glycaemic Control. Diabetes/metabolism research and reviews. 2007;(23):3-13.
13. Gearhart, M. M. & Parbhoo, S. K. Hyperglycemia in the Critically Ill Patient. AACN Advanced Critical Care.2006;(17):50-55.
14. Kapur, A. & Harries, A. D. The Double Burden of Diabetes and Tuberculosis–Public Health Implications. Diabetes Research and Clinical Practice. 2013;(101):10-19.
15. Khariroh & Syamilatul. Faktor Resiko Gagal Konversi BTA Sputum Penderita TB Paru Setelah Program Pengobatan DOTS Fase Intensif di RSU Dr. Soetomo dan PB4 Karang Tembok Surabaya [Tesis]. Surabaya: Universitas Airlangga; 2006.
Authors
Yusnitasari, A. S., M.Thaha, I. L., & Syafar, M. (2016). KOMORBIDITAS DIABETES MELLITUS TERHADAP MANIFESTASI KLINIK DAN KUALITAS HIDUP PADA PENDERITA TUBERKULOSIS PARU. Media Kesehatan Masyarakat Indonesia, 11(2), 86-91. https://doi.org/10.30597/mkmi.v11i2.529
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