KHASIAT MADU MENURUNKAN TEKANAN DARAH DAN HEMATOLOGI PARAMETER
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Abstract
Angka kejadian Diabetes Melitus (DM) terus mengalami peningkatan, baik di dunia, regional, maupun di Indonesia. Salah satu penyebab DM adalah stres oksidatif, sehingga madu sebagai antioksidan alami mampumenurunkan komplikasi yang terjadi. Penelitian ini bertujuan menilai efek pemberian madu terhadap tekanan darah dan hematologi parameter. Jenis rancangan yang digunakan adalah quasi experiment dengan desain prepost control. Populasi adalah penderita DM tipe 2 di dua wilayah kerja puskesmas di Kota Makassar. Sampel adalah sebagian yang memenuhi kriteria inklusi sebanyak 36 penderita DM tipe 2 yaitu 18 responden kelompok intervensi (KI) (diberikan madu dan edukasi gizi), dan 18 responden kelompok kontrol (KII) (diberikan edukasi gizi). Analisis data menggunakan uji Wilcoxon dan uji Mann-Whitney U. Hasil penelitian yaitu terjadi penurunan signifikan kadar kolesterol total, LDL, Gula Darah Puasa (GDP) dan Tekanan Darah Diastolik (TDD) pada KI. KII terjadi penurunan signifikan pada kadar LDL dan GDP, tetapi terjadi peningkatan signifikan pada TDD. Terjadi perbedaan yang signifikan pada TDD antara KI dengan KII (p=0,04). Pemberian madu memberi perubahan positifpada GDP (26,2%), total kolesterol (8,3%), LDL (11,7%), HDL (5,4%), tekanan darah sistolik (TDS) (4,1%) dan TDD (9,1%). Kesimpulan dari penelitian bahwa madu menurunkan kadar GDP, kolesterol total, LDL, TDD dan TDS pada penderita DM tipe 2.
References
1. Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U, Shaw J. Global Estimates of Diabetes Prevalence for 2013 and Projections For 2035. Diabetes Research and Clinical Practice. 2014;103(2):137-149.
2. Ramachandran A, Snehalatha C, Shetty AS, Nanditha A. Trends in Prevalence of Diabetes in Asian Countries. World J Diabetes.2012;3(6):110-117.
3. World Health Organization . Global Action Plan for The Prevention and Control of Non communicable Diseases 2013-2020;2013.
4. Riskesdas 2007. Riset Kesehatan Dasar 2007.Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan Republik Indonesia;2007.
5. Han S, Lee K, Yeo J, Et Al. Effect of Honey Bee Venom on Microglial Cells Nitric Oxide and Tumor Necrosis Factor Α Production Stimulated By LPS. Journal of Ethnopharmacology. 2007;111(1):176-181.
6. Fendler A, Jung M, Stephan C, Et Al. Mirnas Can Predict Prostate Cancer Biochemical Relapse and Are Involved in Tumor Progression. International Journal of Oncology. 2011;39(5):1183-1192.
7. Van Den Berg A, Van Den Worm E, Quarles Van Ufford H, Halkes S, Hoekstra M, Beukelman C. An in Vitro Examination of The Antioxidant and Anti Inflammatory Properties of Buckwheat Honey. Journal of Wound Care.2008;17(4):172-179.
8. Yaghoobi R, Kazerouni A. Evidence For Clinical Use of Honey In Wound Healing As An Anti Bacterial, Anti Inflammatory Anti Oxidant And Anti Viral Agent: A Review. Jundishapur Journal of Natural Pharmaceutical Products. 2013;8(3):100-104.
9. Mohamed M, Sirajudeen K, Swamy M, Yaacob M, Sulaiman S. Studies On The Antioxidant Properties of Tualang Honey Of Malaysia. African Journal of Traditional, Complementary and Alternative Medicines. 2010;7(1).
10. Ferreira IC, Aires E, Barreira JC, Estevinho LM. Antioxidant Activity Of Portuguese Honey Samples: Different Contributions of The Entire Honey and Phenolic Extract. Food Chemistry. 2009;114(4):1438-1443.
11. Al-Waili NS, Boni NS. Natural Honey Lowers Plasma Prostaglandin Concentrations In Normal Individuals. Journal of Medicinal Food.2003;6(2):129-133.
12. Mahesh A, Shaheetha J, Thangadurai D, Muralidhara Rao D. Protective Effect of Indian Honey on Acetaminophen Induced Oxidative Stress and Liver Toxicity In Rat. Biologia.2009;64(6):1225-1231.
13. Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Hepatoprotective Effect of Tualang Honey Supplementation In Strep tozotocin Induced Diabetic Rats. International Journal of Applied Research In Natural Products. 2012;4(4):37-41.
14. Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Et Al. Natural Honey and Cardiovascular Risk Factors; Effects on Blood Glucose, Cholesterol, Triacylglycerole, CRP, and Body Weight Compared With Sucrose. The Scientific World Journal. 2008;8:463-469.
15. Abdulrhman MM, El-Hefnawy MH, Aly RH,Et Al. Metabolic Effects of Honey In Type 1 Diabetes Mellitus: A Randomized Cross- over Pilot Study. Journal of Medicinal Food. 2013;16(1):66-72.
16. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes Estimates For The Year 2000 And Projections For 2030. Di- abetes Care. 2004;27(5):1047-1053.
17. White JW, Subers MH, Schepartz AI. The Identification of Inhibine, The Antibacterial Factor In Honey, As Hydrogen Peroxide and Its Origin In A Honey Glucose-Oxidase System. Biochimica Et Biophysica Acta (BBA) Specialized Section On Enzymological Subjects.1963;73(1):57-70.
18. Adjlane N, Tarek E-O, Haddad N. Evaluation of Oxalic Acid Treatments Against The Mite Varroa Destructor and Secondary Effects on Honey Bees Apis Mellifera. Journal Of Arthropod-Borne Diseases. 2015.
19. Cheng N, Du B, Wang Y, Et Al. Antioxidant Properties Of Jujube Honey and Its Protective Effects Against Chronic Alcohol Induced Liver Damage In Mice. Food & Function.2014;5(5):900-908.
20. Erguder BI, Kilicoglu SS, Namuslu M, Et Al. Honey Prevents Hepatic Damage Induced By Obstruction of The Common Bile Duct. World J Gastroenterol. 2008;14(23):3729-3732.
21. Al Ameen N, Musa O. Effect of Nigella Sativa and Bee Honey On Pulmonary, Hepatic and Renal Function In Sudanese In Khartoum State. J Med Plant Res. 2011;5(31):6857-6863.
22. Erejuwa OO, Sulaiman SA, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Glibenclamide Or Metformin Combined With Honey Improves Glycemic Control In Streptozotocin Induced Diabetic Rats. Int J Biol Sci. 2011;7(2):244-252.
23. Erejuwa O, Sulaiman S, Wahab M, Sirajudeen KS, Salleh S, Gurtu S. Effect Of Glibenclamide Alone Versus Glibenclamide and Honey On Oxidative Stress In Pancreas Of Streptozotocin-Induced Diabetic Rats. International Journal Of Applied Research In Natural Products. 2011;4(2):1-10.
24. Mahendra H. Gambaran Demografi dan Pro- fil Lipid Pasien Penyakit Perlemakan Hati Non-Alkoholik Dengan Riwayat Dislipidemia Di RSUP Fatmawati Pada Tahun 2013-2014 [Skripsi]. Jakarta; Universitas Islam Negeri Syarif Hidayatullah; 2015.
25. Widiastuti E. Perbedaan Kafar Ldl-Kolester- ol Metoda Direk Dengan Formula Fridewold (Pada Penderita Diabetes Melitus) [Tesis]. Semarang; Program Pendidikan Pasca Sarjana Universitas Diponegoro; 2003.
26. Erejuwa OO, Sulaiman SA, Ab Wahab MS.Honey: A Novel Antioxidant. Molecules. 2012;17(4):4400-4423.
27. Erejuwa OO, Sulaiman SA, Wahab MSA, Sirajudeen KN, Salleh MSM, Gurtu S. Differential Responses To Blood Pressure And Oxidative Stress In Streptozotocin-Induced Diabetic Wistar-Kyoto Rats And Spontaneously Hypertensive Rats: Effects Of Antioxidant (Honey) Treatment. International Journal Of Molecular Sciences. 2011;12(3):1888-1907.
28. Attia W, Gabry M, El-Shaikh K, Othman G.The Anti-Tumor Effect Of Bee Honey In Ehrlich Ascite Tumor Model Of Mice Is Coincided With Stimulation Of The Immune Cells. Egypt J Immunol. 2008;15(2):169-183.
29. El-Khayat Z, Ezzat A, Arbid M, Rasheed W, Elias T. Potential Effects Of Bee Honey And Propolis Against The Toxicity Of Ochratoxin A In Rats. Macedonian Journal Of Medical Sciences. 2009;2(4):311-318.
30. Aliyu M, Odunola OA, Owumi SE, Et Al. Dai- ly Consumption Of Honey: Effects On Male Wister Albino Rats. International Journal Of Food And Safety. 2012;1(330):66-74.
31. Afroz R, Tanvir E, Hossain MF, Et Al. Protec- tive Effect Of Sundarban Honey Against Acet- aminophen-Induced Acute Hepatonephrotox- icity In Rats. Evidence-Based Complementary and Alternative Medicine. 2014;2014.
32. Khalil M, Sulaiman S. The Potential Role of Honey and Its Polyphenols In Preventing Heart Disease: A Review. African Journal of Traditional, Complementary and Alternative Medicines. 2010;7(4).
2. Ramachandran A, Snehalatha C, Shetty AS, Nanditha A. Trends in Prevalence of Diabetes in Asian Countries. World J Diabetes.2012;3(6):110-117.
3. World Health Organization . Global Action Plan for The Prevention and Control of Non communicable Diseases 2013-2020;2013.
4. Riskesdas 2007. Riset Kesehatan Dasar 2007.Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan Republik Indonesia;2007.
5. Han S, Lee K, Yeo J, Et Al. Effect of Honey Bee Venom on Microglial Cells Nitric Oxide and Tumor Necrosis Factor Α Production Stimulated By LPS. Journal of Ethnopharmacology. 2007;111(1):176-181.
6. Fendler A, Jung M, Stephan C, Et Al. Mirnas Can Predict Prostate Cancer Biochemical Relapse and Are Involved in Tumor Progression. International Journal of Oncology. 2011;39(5):1183-1192.
7. Van Den Berg A, Van Den Worm E, Quarles Van Ufford H, Halkes S, Hoekstra M, Beukelman C. An in Vitro Examination of The Antioxidant and Anti Inflammatory Properties of Buckwheat Honey. Journal of Wound Care.2008;17(4):172-179.
8. Yaghoobi R, Kazerouni A. Evidence For Clinical Use of Honey In Wound Healing As An Anti Bacterial, Anti Inflammatory Anti Oxidant And Anti Viral Agent: A Review. Jundishapur Journal of Natural Pharmaceutical Products. 2013;8(3):100-104.
9. Mohamed M, Sirajudeen K, Swamy M, Yaacob M, Sulaiman S. Studies On The Antioxidant Properties of Tualang Honey Of Malaysia. African Journal of Traditional, Complementary and Alternative Medicines. 2010;7(1).
10. Ferreira IC, Aires E, Barreira JC, Estevinho LM. Antioxidant Activity Of Portuguese Honey Samples: Different Contributions of The Entire Honey and Phenolic Extract. Food Chemistry. 2009;114(4):1438-1443.
11. Al-Waili NS, Boni NS. Natural Honey Lowers Plasma Prostaglandin Concentrations In Normal Individuals. Journal of Medicinal Food.2003;6(2):129-133.
12. Mahesh A, Shaheetha J, Thangadurai D, Muralidhara Rao D. Protective Effect of Indian Honey on Acetaminophen Induced Oxidative Stress and Liver Toxicity In Rat. Biologia.2009;64(6):1225-1231.
13. Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Hepatoprotective Effect of Tualang Honey Supplementation In Strep tozotocin Induced Diabetic Rats. International Journal of Applied Research In Natural Products. 2012;4(4):37-41.
14. Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Et Al. Natural Honey and Cardiovascular Risk Factors; Effects on Blood Glucose, Cholesterol, Triacylglycerole, CRP, and Body Weight Compared With Sucrose. The Scientific World Journal. 2008;8:463-469.
15. Abdulrhman MM, El-Hefnawy MH, Aly RH,Et Al. Metabolic Effects of Honey In Type 1 Diabetes Mellitus: A Randomized Cross- over Pilot Study. Journal of Medicinal Food. 2013;16(1):66-72.
16. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes Estimates For The Year 2000 And Projections For 2030. Di- abetes Care. 2004;27(5):1047-1053.
17. White JW, Subers MH, Schepartz AI. The Identification of Inhibine, The Antibacterial Factor In Honey, As Hydrogen Peroxide and Its Origin In A Honey Glucose-Oxidase System. Biochimica Et Biophysica Acta (BBA) Specialized Section On Enzymological Subjects.1963;73(1):57-70.
18. Adjlane N, Tarek E-O, Haddad N. Evaluation of Oxalic Acid Treatments Against The Mite Varroa Destructor and Secondary Effects on Honey Bees Apis Mellifera. Journal Of Arthropod-Borne Diseases. 2015.
19. Cheng N, Du B, Wang Y, Et Al. Antioxidant Properties Of Jujube Honey and Its Protective Effects Against Chronic Alcohol Induced Liver Damage In Mice. Food & Function.2014;5(5):900-908.
20. Erguder BI, Kilicoglu SS, Namuslu M, Et Al. Honey Prevents Hepatic Damage Induced By Obstruction of The Common Bile Duct. World J Gastroenterol. 2008;14(23):3729-3732.
21. Al Ameen N, Musa O. Effect of Nigella Sativa and Bee Honey On Pulmonary, Hepatic and Renal Function In Sudanese In Khartoum State. J Med Plant Res. 2011;5(31):6857-6863.
22. Erejuwa OO, Sulaiman SA, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Glibenclamide Or Metformin Combined With Honey Improves Glycemic Control In Streptozotocin Induced Diabetic Rats. Int J Biol Sci. 2011;7(2):244-252.
23. Erejuwa O, Sulaiman S, Wahab M, Sirajudeen KS, Salleh S, Gurtu S. Effect Of Glibenclamide Alone Versus Glibenclamide and Honey On Oxidative Stress In Pancreas Of Streptozotocin-Induced Diabetic Rats. International Journal Of Applied Research In Natural Products. 2011;4(2):1-10.
24. Mahendra H. Gambaran Demografi dan Pro- fil Lipid Pasien Penyakit Perlemakan Hati Non-Alkoholik Dengan Riwayat Dislipidemia Di RSUP Fatmawati Pada Tahun 2013-2014 [Skripsi]. Jakarta; Universitas Islam Negeri Syarif Hidayatullah; 2015.
25. Widiastuti E. Perbedaan Kafar Ldl-Kolester- ol Metoda Direk Dengan Formula Fridewold (Pada Penderita Diabetes Melitus) [Tesis]. Semarang; Program Pendidikan Pasca Sarjana Universitas Diponegoro; 2003.
26. Erejuwa OO, Sulaiman SA, Ab Wahab MS.Honey: A Novel Antioxidant. Molecules. 2012;17(4):4400-4423.
27. Erejuwa OO, Sulaiman SA, Wahab MSA, Sirajudeen KN, Salleh MSM, Gurtu S. Differential Responses To Blood Pressure And Oxidative Stress In Streptozotocin-Induced Diabetic Wistar-Kyoto Rats And Spontaneously Hypertensive Rats: Effects Of Antioxidant (Honey) Treatment. International Journal Of Molecular Sciences. 2011;12(3):1888-1907.
28. Attia W, Gabry M, El-Shaikh K, Othman G.The Anti-Tumor Effect Of Bee Honey In Ehrlich Ascite Tumor Model Of Mice Is Coincided With Stimulation Of The Immune Cells. Egypt J Immunol. 2008;15(2):169-183.
29. El-Khayat Z, Ezzat A, Arbid M, Rasheed W, Elias T. Potential Effects Of Bee Honey And Propolis Against The Toxicity Of Ochratoxin A In Rats. Macedonian Journal Of Medical Sciences. 2009;2(4):311-318.
30. Aliyu M, Odunola OA, Owumi SE, Et Al. Dai- ly Consumption Of Honey: Effects On Male Wister Albino Rats. International Journal Of Food And Safety. 2012;1(330):66-74.
31. Afroz R, Tanvir E, Hossain MF, Et Al. Protec- tive Effect Of Sundarban Honey Against Acet- aminophen-Induced Acute Hepatonephrotox- icity In Rats. Evidence-Based Complementary and Alternative Medicine. 2014;2014.
32. Khalil M, Sulaiman S. The Potential Role of Honey and Its Polyphenols In Preventing Heart Disease: A Review. African Journal of Traditional, Complementary and Alternative Medicines. 2010;7(4).
Authors
Jafar, N., Hamid, S. K., Citrakesumasari, C., Najamuddin, U., & Syam, A. (2017). KHASIAT MADU MENURUNKAN TEKANAN DARAH DAN HEMATOLOGI PARAMETER. Media Kesehatan Masyarakat Indonesia, 13(1), 27-33. https://doi.org/10.30597/mkmi.v13i1.1586
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